22/07/2025
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Caffeine triggers cellular pathway linked to longer lifespan, study finds
Caffeine may offer more than just a morning jolt—it could also play a role in extending cell life and promoting healthier aging.
A new study from Queen Mary University of London and the Francis Crick Institute reveals that caffeine activates AMPK, an enzyme known as the cell’s “fuel gauge,” which helps manage energy use, repair DNA, and respond to cellular stress.
These are all key factors in slowing the biological aging process. Unlike other longevity-related compounds, caffeine doesn’t directly inhibit the TOR pathway (a major controller of cell growth), but rather modulates it through AMPK, offering a new angle on how caffeine might influence health at the cellular level.
Using fission yeast as a model organism, the researchers demonstrated how caffeine triggers this cascade of beneficial effects, leading to improved cell function and lifespan extension. These findings reinforce past observational links between caffeine and various health benefits, including reduced risk of dementia, lower body fat, and better cardiovascular health. While human studies are still needed, this research helps explain the molecular mechanics behind caffeine’s potential anti-aging properties and opens new avenues for developing age-related therapies.
Source: Alao, J.-P., Kumar, J., Stamataki, D., & Rallis, C. (2025). Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast. Microbial Cell.